65-90% of cases of viral conjunctivitis are caused by human adenovirus. Ocular manifestations of adenoviral infection are epidemic keratoconjunctivitis, pharyngo-conjunctival fever, acute non-specific follicular conjunctivitis, and chronic keratoconjunctivitis. The actual clinical case is about a 50-year-old patient, addressed for eye discomfort, foreign body sensation, photophobia, epiphora, blurred vision in the left eye. The diagnosis of adenoviral keratoconjunctivitis was established based on clinical findings. It was decided to institute topical antiviral treatment (Ganciclovir gel), anti-inflammatory (corticosteroids), antimicrobial hepatoprotectivetive therapy. The treatment was successful, with a favorable evolution and complete healing.