Eleven consecutive patients who presented with priapism were treated with 0,5 mg phenylephrine diluted in 2 ml normal saline injected directly into the corpus cavernosum. The aim of this study was to assess the effectiveness and complications of intracorporeal phenylephrine administration without aspiration or irrigation as a treatment for priapism. Blood pressure and pulse were measured before and after injection, and monitored every 15 minutes. If no detumescence was noted after 15 minutes, the injection was repeated. Neither penile blood aspiration, nor irrigation was performed. 9 of 11 responded with detumescence. The number of injections required ranged from 1 to 6. No changes in blood pressure, heart rate or side effects were observed. We believe that this is a safe and effective method for treatment of priapism. Routine initial aspiration or irrigation of the corpora before intracorporeal injection of adrenergic agents does not appear to be necessary.