Pollution and contamination of drinking water potentially cause severe problems to health so the water quality management addresses both national and international action to assess and prevent associated hazards. A survey to study natural radioactivity in drinking water was carried out in the Republic of Moldova. Approximately 3111 samples of drinking water were analyzed between 1985-1999 and 2011-2015. The samples were categorized according to their origin: bottled or public supply. The samples were analyzed for gross beta, 220Rn, 222Rn, 137Cs and 90Sr activity. The activity concentration for gross beta was found to range from 0.41 to 1.53 Bq/L. The gross beta activity content in the majority of the samples is due to 40K. Average concentrations of 137Cs and 90Sr activity in the studied waters ranged respectively from 0.02 to 3.2 Bq/L and 0.012 to 2.2 Bq/L. Regarding radon detection, the results showed that the average concentration of radon in artesian wells was 1.93 Bq/m³; in the aqueduct water – 3.12 Bq/m³; in the spring waters – 6.17 Bq/m³; in wells – 3.87 Bq/m³, in bottled water – 0.1 Bq/l, in mine water – 0.93 Bq/l and in the surface water about 1 Bq/m³. It was stated that 222Rn concentrations in the surveyed waters did not exceed the permissible values according to national rules and Directive 2013/59/EURATOM.