An important factor in health protection is the provision of the population with good-quality drinking water. It is one of the main environmental factors that can have both positive and negative effects on the health of the population. To assess possible negative consequences for the health of the population, water samples were taken from the Uvod reservoir, which is the main source of water supply for the city of Ivanovo. The results obtained allow us to conclude that the water body, according to the integrated WPI indicator, for 2021 belongs to the 6th class – very dirty. However, taking into account the dynamics for the period 2019 – 2021, there is a negative trend, which leads to a deterioration in the state of the water body, and as a consequence to a low quality of drinking water. The list of monitored indicators was formed on the basis that they are included in the list regulated by regulations and are typical pollutants for the investigated water body. It was found that the main contribution to WPI and the greatest contribution to the value of general toxic risk (development of chronic intoxication) and the risk of developing adverse organoleptic effects (chronic intoxication) are made by Cu, Mn and Fe. Perhaps this is due to the increasing anthropogenic load, namely, the development of the banks by private households and the use of the facility for recreational purposes. The results obtained show that it is necessary to implement measures aimed at reducing the level of pollution, both of water in the reservoir and water in the centralized water supply system of Ivanovo.