Introduction. During post-stroke rehabilitation, medical specialists can report a wide range of comorbidities. Many healthcare providers use International Classification of Disease 10 (ICD 10) in order to monitor the occurrence of multiple conditions. Even though ICD 10 remains a common tool of monitoring the comorbidities, its application for post stroke rehabilitation remains unclear. Purpose of the study. To determine whether the ICD 10 model is adequate for assessing comorbidity patterns of post stroke persons enrolled in rehabilitation. Material and methods. Comorbidity profiles of 252 persons with stroke admitted to Neurological Rehabilitation department and frequencies of events according to recorded ICD-10 system was assessed. Results: 81 different codes recorded according to ICD -10 (among them 32 codes single entries), were attributed to risk factors, complication and concomitant disease as groups of comorbidities. Diseases of the circulatory system (I00-I99) was in the top of comorbidities profiles counting 601 entries as follows: hypertensive heart failure - 154 cases, atrial fibrillation - 67 cases, carotid arteries occlusion 56 cases and others. Among the codes, representing risk factors, and concomitant disease were endocrine/ nutritional and metabolic diseases (E00-99) represented by diabetes – 77 cases, obesity - 37 cases. Functional deficits presented mainly by codes of hemiplegia (G81) - 140 cases and speech disorders (R47) in 119 cases. Mental/ behavior disorders (F00-99) or musculoskeletal diseases (M00-99) were another important groups of comorbidities that belong to complications. At the same time, it was difficult to present ICD-10 codes to a specific group of comorbidities. Combination of ICD-10 with functional classifications and comorbidity indexes can provide more clearness. Conclusions: ICD-10 system offers important information upon comorbidities encountered within rehabilitation post stroke but its use remains challenging / with gaps in monitoring comorbidities.