The impact of the global determinants on the world economy development is investigated in the research under way. The authors classified determinants in the main groups such as economic, geopolitical, environmental, social and technological determinants by the level of their impact. The study of the specifics of their impact is correlated with the global risks that determine the peculiarities of the world economy development. Based on the analysis, it is substantiated that the degree of influence of all determinants groups is quite significant, but is characterized by a certain level of differentiation. Geopolitical and geoeconomic uncertainties remain the most significant determinants by the relative impact level on the world economic development. Key determinants such as the level of countries economic development, the environmental issues, the level of technologies development and health care remain important, and stakeholders must find ways to quickly and effectively respond within the existing global landscape to change and influence them.