Synthesis of some new homodrimane derivatives of benzothiazole from norambreinolide

Blaja Svetlana; Aricu Aculina; Kuchkova Kaleria; Barba Alic

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2023-12-28 17:09

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547.814.1.07 (1)

Органическая химия (484)

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BLAJA, Svetlana, ARICU, Aculina, KUCHKOVA, Kaleria, BARBA, Alic. Synthesis of some new homodrimane derivatives of benzothiazole from norambreinolide. In: New frontiers in natural product chemistry.: A destiny on the altar of research. Dedicated to academician Pavel Vlad, Ed. 6, 21 mai 2021, Chișinău. Chișinău, Republica Moldova: Tipografia "Artpoligraf", 2021, Ediția 6, p. 33. ISBN 978-9975-3336-7-2. DOI: https://doi.org/10.19261/nfnpc.2021.ab26

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New frontiers in natural product chemistry.
Ediția 6, 2021

Conferința " New frontiers in natural product chemistry."
6, Chișinău, Moldova, 21 mai 2021

Synthesis of some new homodrimane derivatives of benzothiazole from norambreinolide

DOI:https://doi.org/10.19261/nfnpc.2021.ab26

CZU: 547.814.1.07

Pag. 33-33

Blaja Svetlana, Aricu Aculina, Kuchkova Kaleria, Barba Alic

Institute of Chemistry

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Menționat în lucrare: 20.80009.8007.03 Noi substanțe cu potențial preventiv și terapeutic în baza compușilor naturali de origine vegetală și a matodelor moderne de sinteză organică

Disponibil în IBN: 28 mai 2021

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Many drimane and homodrimane sesquiterpenoids, including those containing nitrogen, are known to exhibit a variety of biological activities [1]. The search of new biologically active compounds prompted us to synthesize homodrimane sesquiterpenoids (4) and (6), containing benzothiazole fragment. Starting Δ8-bicyclohomofarnesoic acid (2) and Δ6,8-bicyclohomofarnesoic acid (5) were obtained from commercially available norambreinolide (1). Reaction of these acids with 2-aminothiophenole (3) produce 2-(Δ8-bicyclohomofarnesyl)-benzothiazole (4) and 2-(Δ6,8-bicyclohomofarnesyl)benzothiazole (6), accordingly. Reagents and conditions: a. Ph3P, Et3N, CCl4, Δ, 4 h. The structures of the newly obtained compounds were established on the basis of their spectral date (IR, 1H- and 13C-NMR, mass-spectra).

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<dc:creator>Blaja, S.</dc:creator>
<dc:creator>Arîcu, A.N.</dc:creator>
<dc:creator>Cucicova, C.</dc:creator>
<dc:creator>Barbă, A.N.</dc:creator>
<dc:date>2021</dc:date>
<dc:description xml:lang='en'><p>Many drimane and homodrimane sesquiterpenoids, including those containing nitrogen, are known to exhibit a variety of biological activities [1]. The search of new biologically active compounds prompted us to synthesize homodrimane sesquiterpenoids (4) and (6), containing benzothiazole fragment. Starting &Delta;8-bicyclohomofarnesoic acid (2) and &Delta;6,8-bicyclohomofarnesoic acid (5) were obtained from commercially available norambreinolide (1). Reaction of these acids with 2-aminothiophenole (3) produce 2-(&Delta;8-bicyclohomofarnesyl)-benzothiazole (4) and 2-(&Delta;6,8-bicyclohomofarnesyl)benzothiazole (6), accordingly. Reagents and conditions: a. Ph3P, Et3N, CCl4, &Delta;, 4 h. The structures of the newly obtained compounds were established on the basis of their spectral date (IR, 1H- and 13C-NMR, mass-spectra).</p></dc:description>
<dc:identifier>10.19261/nfnpc.2021</dc:identifier>
<dc:source>New frontiers in natural product chemistry. (Ediția 6) 33-33</dc:source>
<dc:title>Synthesis of some new homodrimane derivatives of benzothiazole from norambreinolide</dc:title>
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