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 SM ISO690:2012MACAROV, Serghei, SALNIKOV, Denis, POGORELOVA, Anna, KISC, Zoltan, SILAGHI-DUMITRESCU, Radu. A new route to carbon monoxide adducts of HEME proteins. In: International Conference of Young Researchers , 6-7 noiembrie 2008, Chişinău. Chişinău: Tipogr. Simbol-NP SRL, 2008, Ediția 6, p. 80. ISBN 978-9975-70-769-5. |
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| International Conference of Young Researchers Ediția 6, 2008 |
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Conferința "International Conference of Young Researchers " Chişinău, Moldova, 6-7 noiembrie 2008 | ||||||
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Sulfoxylate SO2H- (SO2 2-), a strong reducing agent readily produced by hydrolysis of thiourea dioxide, reacts with ferric myoglobin (Mb) to reversibly produce Fe(II)-Mb, starting from either aerobic or anaerobic conditions. Exposure of Fe(II)-Mb to excess sulfoxylate further produces Fe(II)-CO-Mb. Fe(II)-Mb can be regenerated by reoxidation with ferricyanide at this stage; hemin, rubredoxin and cytochrome c show a similar reactivity towards sulfoxylate. The source of CO is not the protein moiety, nor is it the heme or the thiourea dioxide – but rather CO2, via its reaction with sulfoxylate when the latter is used in large excess. These findings provide a convenient single-step route to carbon monoxide heme adducts, without the need to manipulate toxic CO gas. Financial support from the Romanian Ministry of Education and Research, (CEEx-ET98/2006, to RSD), Russian Foundation for Basic Research and Romanian Academy (joint grant to RSD and SVM), and “Babes-Bolyai” University (Scholarship for Scientific Research to KZ) is gratefully acknowledged. |
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| Cuvinte-cheie myoglobin, Hemoglobin, heme, Carbon monoxide, dithionite, sulfoxylate, thiourea dioxide |
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DataCite XML Export
<?xml version='1.0' encoding='utf-8'?> <resource xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xmlns='http://datacite.org/schema/kernel-3' xsi:schemaLocation='http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd'> <creators> <creator> <creatorName>Macarov, S.</creatorName> <affiliation>Ivanovo State University of Chemistry and Technology, Rusia</affiliation> </creator> <creator> <creatorName>Salnikov, D.S.</creatorName> <affiliation>Ivanovo State University of Chemistry and Technology, Rusia</affiliation> </creator> <creator> <creatorName>Pogorelova, A.S.</creatorName> <affiliation>Ivanovo State University of Chemistry and Technology, Rusia</affiliation> </creator> <creator> <creatorName>Kisc, Z.</creatorName> <affiliation>Universitatea „Babeş-Bolyai”, Cluj-Napoca, România</affiliation> </creator> <creator> <creatorName>Silaghi-Dumitrescu, R.</creatorName> <affiliation>Universitatea „Babeş-Bolyai”, Cluj-Napoca, România</affiliation> </creator> </creators> <titles> <title xml:lang='en'>A new route to carbon monoxide adducts of HEME proteins</title> </titles> <publisher>Instrumentul Bibliometric National</publisher> <publicationYear>2008</publicationYear> <relatedIdentifier relatedIdentifierType='ISBN' relationType='IsPartOf'>978-9975-62-196-0</relatedIdentifier> <subjects> <subject>myoglobin</subject> <subject>Hemoglobin</subject> <subject>heme</subject> <subject>Carbon monoxide</subject> <subject>dithionite</subject> <subject>sulfoxylate</subject> <subject>thiourea dioxide</subject> </subjects> <dates> <date dateType='Issued'>2008</date> </dates> <resourceType resourceTypeGeneral='Text'>Conference Paper</resourceType> <descriptions> <description xml:lang='en' descriptionType='Abstract'><p>Sulfoxylate SO2H- (SO2 2-), a strong reducing agent readily produced by hydrolysis of thiourea dioxide, reacts with ferric myoglobin (Mb) to reversibly produce Fe(II)-Mb, starting from either aerobic or anaerobic conditions. Exposure of Fe(II)-Mb to excess sulfoxylate further produces Fe(II)-CO-Mb. Fe(II)-Mb can be regenerated by reoxidation with ferricyanide at this stage; hemin, rubredoxin and cytochrome c show a similar reactivity towards sulfoxylate. The source of CO is not the protein moiety, nor is it the heme or the thiourea dioxide – but rather CO2, via its reaction with sulfoxylate when the latter is used in large excess. These findings provide a convenient single-step route to carbon monoxide heme adducts, without the need to manipulate toxic CO gas. Financial support from the Romanian Ministry of Education and Research, (CEEx-ET98/2006, to RSD), Russian Foundation for Basic Research and Romanian Academy (joint grant to RSD and SVM), and “Babes-Bolyai” University (Scholarship for Scientific Research to KZ) is gratefully acknowledged.</p></description> </descriptions> <formats> <format>application/pdf</format> </formats> </resource>
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