Porphyrins are compounds widely applied in photodynamic therapy of tumors. It is known that nanoparticles of colloidal silver due to the porosity are extremely large specific surface, which are an order of magnitude increases their sorption capacity. The aim of this work was to study sorption/desorption of porphyrins on nanoparticles of silver. The engineering of new nanocomposites of inorganic and organic materials is a promising direction. The problem of creating highly specific nanocomposite able to deliver targeted cancer cells affecting agents (photosensitizers) and destroy the tumor is divided into several tasks: a) the formation of an inert inorganic nanocomposite with active sorption surface (colloidal silver); b) the binding of photosensitizers (porphyrins) with inorganic nanocomposites; c) the binding of porphyrins to protein carriers, which are specific / selective binding to the surface of cancer cells; d) the design of the nanocomposite of organic and inorganic constituents, which are highly specific and effective attack cancer cells. The study of the presented problem was carried out by optical spectroscopy using the new program for processing the spectral data to obtain accurate quantitative information on complexation of colloidal silver - porphyrin. The interaction of porphyrin with silver nanoparticles of 20 nm diameter was studied by spectrophotometry in the visible spectrum, in the wavelength range 350-700 nm. Investigation of sorption dynamics of porphyrins in the silver nanoparticles using two porphyrins: a) meso-tetra (4-N-butyl pyridyl) porphyrin (TBut4PyP), b) Ag-meso-tetra (4-N-butyl pyridyl) porphyrin (Ag-TBut4PyP), as well of photosensitizer Al-phthalocyanine were carried out. This two porphyrins were selected by two criteria: first, in experiments on the action on the culture of cancer cells and various microorganisms in vitro, they showed high activity compared with other 20 previously studied porphyrins and metalloporphyrins, secondly, porphyrin Ag-TBut4PyP was chosen to exclude the effect of metallation (the effect of incorporation of ionic forms of Ag in the structure of the porphyrin nucleus). After addition of nanoparticles is a sharp drop in intensity of the absorption spectrum of porphyrins and a slight shift of the absorption peak in the region of longer wavelengths. The observed hypochromic effect (decrease of light absorption intensity) probably can be explained by the appearance of nanoparticleporphyrin complexes in solution, where the porphyrin is in a more structured form compared to its free state. Analysis of the dynamics of change in the absorption spectra for porphyrins TBut4PyP and Ag-TBut4PyP by adding nanoparticles leads to the conclusion that the binding of porphyrins occurs very quickly - less than 3 minutes. For example, the porphyrin Ag-TBut4PyP this conclusion follows from the change of the peak at λ = 430 nm, the initial peak of porphyrin without nanoparticles (A = 1.792); while adding nanoparticles absorption intensity has fallen sharply to A = 1.211 (after 3 minutes) and continued to fall during 3 hours to A = 1,028 (hereat for the last 30 minutes the intensity practically did not change). The stable state of absorption intensity (about A = 1.00) remained at 12 and 24 hours of observations of the spectra of porphyrins. Otherwise picture is observed for Al-phthalocyanine photosensitizer when adding the same nanoparticles. There is also a rapid sorption of photosensitizer Al-phthalocyanine on silver nanoparticles (3 min), hereat at adding of nanoparticles intensity of the initial curve falls slightly. However, in the next 30 minutes the intensity of the absorption curve almost coincides with the original, which apparently can be interpreted as desorption of Al-phthalocyanine from nanoparticles. Farther, this process of desorption continues (curves obtained for 60, 90, 120 min) and comes to a complete desorption of Al-phthalocyanine from nanoparticles. On the basis of experiments calculations of sorption porphyrins TBut4PyP and Ag-TBut4PyP on silver nanoparticles (with thinning of porphyrins and correction value of the peak of the absorption spectra) were carried out, which determined that: for porphyrin TBut4PyP percentage sorption on nanoparticles is 60.7%; for porphyrin Ag-TBut4PyP percentage sorption on nanoparticles is 55.6%. Thus, studies of sorption of the two types of porphyrins on the silver nanoparticles indicates the great possibilities of interaction and carry of cationic porphyrins such nanoparticles, with their potential applications in photodynamic therapy of tumors and inactivation of microorganisms.