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SM ISO690:2012 ARNAUT, Oleg. Modelul predictiv al leziunilor pulmonare la distanță în traumatismul experimental. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 58. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 58-58 | ||||||
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Rezumat | ||||||
Background. Trauma remains a medical-social problem, still having high lethality rate. Indirect lung injury (ILI) occurs in trauma due to systemic neutrophils activation and proteases release into primary intact tissues. There are no data in the literature regarding to ILI predictive models in trauma. Objective of the study. Indirect posttraumatic lung injury predictive model elaboration for hypotheses emitting regarding the pathophysiological mechanisms, prophylaxis and potential therapies of ILI. Material and Methods. In the experimental study (19 traumatized rabbits), the proteases, antiproteases and the pulmonary morphological changes, assessed according to the SAMCRS score (Semicantitative Reflected Calitative Changes Assesment Scale) were followed. There were two statistical instruments correlational analysis and multivariate linear regression. Results. Initially a correlational analysis between the values of the SAMCRS score and the proteases/ anti proteases was performed. The null hypothesis was rejected (F = 7.017, p = .002). The correlation coefficient of the predicted results and the real values of SAMCRSlungs was .854, the determination coefficient being .626. The final model included the following parameters: constant (B = 9,427; 95% CI 7,341, 11,513; p <.001); α2macroglobulin 0 (B = -4,053; 95% Cl -6,350, -1,757; p = .002); AEAMP 0 (B = .002; 95% CI .000, .004; p = .075); AEAMP 24 (B = -. 006; 95% CI -.010, -.002; p = .003); AECG 2 (B = .081; 95% CI .040, .122; p = .001); AEE 0 (B = -. 026; 95% CI -.040, -.011; p = .002). Conclusion. In this research, a predictive model for indirect lung injury in experimental trauma was developed, the predictors being some elements of the proteases/antiproteases system. This, in turn, allows the for hypotheses emitting regarding the pathophysiology, prophylaxis and treatment of ILI. |
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Cuvinte-cheie trauma, indirect lung injury, predictive model, traumă, leziunea pulmonară la distanță, model predictiv |
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