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Articolul urmator |
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SM ISO690:2012 CARACAŞ, Anastasia, VASILACHE, Eugenia. Hepatotoxicitatea colchicinei: caz clinic și reviu al literaturii. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 43. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 43-43 | ||||||
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Rezumat | ||||||
Background. Colchicine demonstrates the greatest anti-mitotic activity on rapidly dividing tissue and has only infrequently been associated with hepatotoxicity. It has usually been associated with cases of overdose in which the hepatic injury has been self-limited and overshadowed by the other toxicities. Objective of the study. The review of literature for argue colchicine hepatotoxicity by elucidating the mechanisms responsible for the toxicity of this drug. Material and Methods. It was analyzed a clinical case of a 68-year-old woman who was treated for 9-month with colchicine 2 mg and allopurinol 100 mg daily, for the treatment of asymptomatic hyperuricemia and an increase in liver transaminases was noted on routine examination. Literature review allowed us to find cases reports of colchicine-induced hepatotoxicity. Results. Transaminases were noted to be mildly abnormal at 6 months after starting colchicine 2 mg daily, but bilirubin fractions, alkaline phosphatase levels were normal. Viral etiology of the liver disease (liver markers - negative), tumor etiology (alpha-fetoproteinnegative), ethyl origin (the patient denied excessive alcohol consumption) were excluded by diagnostic investigations. Abdominal ultrasound was normal. Clinical examination did not determine the presence of chronic liver disease. Liver function was improving gradually after colchicine was discontinued despite administration of allopurinol. Conclusion. Liver damage in the patient was caused by long-term administration of colchicine, confirmed by normalization of liver tests after discontinuation of the drug. The hepatotoxicity of colchicine was determined by direct cytotoxic effect, the formation of metabolites and oxidative stress. |
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Cuvinte-cheie colchicine, hepatotoxicity, cytotoxic action, oxidative stress, colchicina, hepatotoxicitate, acțiune citotoxică, stres oxidativ |
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