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SM ISO690:2012 GHELIMICI, Tatiana, LUPAŞCO, Iulianna, DUMBRAVA, Vlada-Tatiana, CHIRVAS, Elena, BEREZOVSCAIA, Elena, HAREA, Gheorghe. Unii indicatori ai metabolismului la bolnavii cu hepatite cronice virale. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 223. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | |||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | |||||||
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Pag. 223-223 | |||||||
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Background. The study of metabolism parameters in chronic viral hepatitis (CVH) HBV, HCV, HBV + HCV is of interest in the evolution of liver disease. Objective of the study. Evaluation of ceruloplasmin (acute inflammatory phase glycoprotein), cholesterol (cell membrane sterol with immune regulatory functions) and ALT enzyme levels in blood serum of patients with CVH. Material and Methods. 138 patients with HCV were investigated, divided into 3 groups: I - 58 patients (p.) With CVH HBV etiology, II - 69p. with CVH HCV, III - 11 p. with CVH HBV + HCV. Results. Evaluation of obtained data showed increased ALT values in all patients: 88,32 ± 10,38, 122,4 ± 9,78, 156 ± 32,16 IU/l (p˂0,01, p˂0,01, p˂0,01), compared to the control group (CG) – 20,4 ± 1,4 U / l. The ceruloplasmin level showed in group I 355,6 ± 8,4 mg/l (p˂0,05), II – 354,0 ± 8,0 mg/l (p˂0.05), III – 354,16 ± 7.8 mg/l (p˂ 0,05), compared to 344,4 ± 5,6 mg/l in LC a plateau form, possibly caused by impaired hepatic synthesis function. Cholesterol levels in groups I and II were significantly increased 4,5 ± 0.4 mmol/l, 4,34 ± 0.3 mmol / l (p˂0,05, p˂ 0,05), being lower, but abnormal in group III - 3,9 ± 0.14 mmol/l (p˂ 0,05), compared to LC – 3,5 ± 0,15 mmol/l. Conclusion. Serum ceruloplasmin and cholesterol levels undulation in patients with chronic viral hepatitis may serve as markers of liver dysfunction, dysmetabolism, and chronic hepatic inflammatory process. |
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Cuvinte-cheie chronic viral hepatitis, ceruloplasmin, cholesterol, hepatiă cronică virală, ceruloplasmină, colesterol |
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