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Ultima descărcare din IBN: 2023-06-03 17:02 |
![]() BOTEZATU, Adriana, BODRUG, Nicolae, ISTRATE, Viorel. Leziunile precanceroase gastrice: fiziopatologie și simptomatologie. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 188. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 188-188 | ||||||
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Rezumat | ||||||
Background. Independent risk factors for atrophic gastritis, intestinal metaplasia (IM) and gastric cancer (GC) are: H.pylori (HP) infection, genetic factors (old age, male sex, family history of gastric cancer), as well as other external factors: smoking, alcohol, prolonged use of proton pomp inhibitor etc. Objective of the study. Elaborating of a narrative synthesis of contemporary studies on the pathophysiology and clinical picture of precancerous gastric lesions (PGL) and their role in the development of GC. Material and Methods. Publications were selected from the PubMed, Hinari and SpringerLink databases by keywords: chronic atrophic gastritis (CAG), IM, dysplasia, GC, HP. According to the search criteria, 563 complete articles were found. After processing the information, we selected 46 relevant sources for the materials published on the topic of this synthesis article. Results. Atrophic gastritis associated with HP infection progresses on two topographic patterns: the first pattern, most common in Western countries, is represented by antral CAG - inflammation located predominantly in the gastric antrum; the second model is the multifocal CAG. The special virulence of HP CagApositive strains, with a role in the evolution towards GC, is widely accepted. CAG is not a normal aging process, but it is the result of HP infection. A low risk of IM among HP-negative women may partially explain the lower prevalence of GC in women compared to men. PGL are multi-faceted conditions with a variable spectrum of gastric and extra-gastric symptoms. Conclusion. HP infection and inflammatory cells induce various pathological lesions in the gastric mucosa. In contrast to the classic perception of a silent condition, patients with PGL report a wide range of symptoms, from dyspepsia to gastroesophageal reflux. |
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Cuvinte-cheie atrophic gastritis, intestinal metaplasia, gastric cancer, H.pylori, gastrită atrofică, metaplazie intestinală, cancer gastric, H.pylori |
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