Introduction. The prevalence of endocrine disorders is increasing worldwide. Type 2 diabetes and thyroiditis is increasingly prevailing in the Republic of Moldova. Contemporary endocrine medical service is successful both in special stationary, ambulatory and domestic conditions. In the administration of the permanent treatment, it is necessary to comply with appropriate bioethical principles.  Aim of the study. Revealing the particularities and role of the involvement of bioethical principles in the endocrine medical act.  Materials and methods. Scientific, statistical, sociological and bioethical publications from the country and abroad were consulted. There were used systemic, statistical, and bioethical methods.  Results. The study of type 2 diabetes and thyroiditis is a priority public health issue in the Republic of Moldova and the world. The inclusion of bioethics in medication involves the reassessment of some methodological principles in the realization of the medical act and the inclusion of innovative issues in the doctor-patient relations.  Conclusions. (1) The particularities of the endocrine medical act have been emphasized from the point of view of some bioethical principles. (2) The efficacy of the medication was improved by applying the bioethical aspects in the physician-patient relationship. (3) The most important bioethical principles are: confidentiality and therapeutic integrity.