The Ecological Status of sediments in MONITOX network area was established using different indices. In spring 2019, during national trip, it was collected 32 sediment samples in the system of Danube river Black Sea, as follows: Lower Danube RO-BG (1), Lower Danube RO (10), Lower Prut RO-MD border (2), Danube Delta RO-UA border (7), Danube Delta –RO (2), Black-Sea area-RO (10). The heavy metals (Cd, Cr, Cu, Pb, Zn, Mn) were extracted using the microwave oven Anton Paar and analysed using ICP-MS Elan DRCe Perkin Elmer. In order to comprehensively understand the contamination of heavy metals in the sediments, there were calculated the Single Ecological Risk Index (Er Me), Contamination Factor (CF Me), Enrichment Factor (EF Me), Geoaccumulation Index (Igeo Me). The selected heavy metals concentrations were integrated together with the standard quality levels, background concentrations in 3 indices: Ecological Risk Index (RI), Global Pollution Index (PLI) and Nemerow Pollution Index (PI N). All indices were reported to the corresponding quality classes. Ecological risk factor of heavy metals, (ErMe), quantitatively calculated to express the potential ecological risk, have values corresponding to low ecological risk for sediments (ErMe<40). All the sediments are deficiency to minimal enrichment with Cd, Cu, Pb, Zn (EFMe<2). The sediments from Black-Sea area, have the EFMe<1.5, suggest that the trace metal concentration may come entirely from natural weathering processes. The sediment from Lower Danube RO-BG presents moderate enrichment with chromium and significant enrichment from Lower Danube RO, due to anthropogenic activities.The contamination factor (CFMe), considered to be a simple and effective tool in monitoring the heavy metal contamination, has values corresponding to low pollution level with Cd, Cu, Pb, Zn (CFMe<1). For Cr, the sediments from Lower Danube RO-BG and Black Sea area-RO have low pollution level and the others have moderate pollution level (1≤CFMe<3). According with Geoaccumulation Index for Cd, Cr, Cu, Pb, Zn, all the sediments are unpolluted (Igeo Me<0). At the integrated levels, taking into accounts the Risk Index, the heavy metals have low ecological risk for sediments (RI<150). The values of Global Pollution Index indicate that the sediments are unpolluted with heavy metals (PLI<1) and from Nemerow Pollution Index values, it results that the sediments are not contaminated with heavy metals (PIN<1). At individual level, but also at integrative level, the sediments from the Black Sea area have the minimum contamination with heavy metals and the sediments from Lower Danube RO area have the maximum contamination, fact possible attributed to the historical pollution resulting from anthropogenic activities.