Introduction. The Midline lum bar interbody fusion (MIDLIF) uses the cortical bone trajectory (CBT) pedicle screws instead of the traditional pedicle screws. The CBT screw follows a medial to lateral path in the transverse plane and is tilted caudally in the sagittal plane. This techni que is minimally invasive, reinforces the screw pullout strength and reduces the approach related morbidity. Aim of the study. To explore the outcomes of MIDLIF technique application. Materials and methods. Between December 2015 and December 2017, 36 pati ents (14 men and 22 women) underwent MIDLIF for degenerative spondylosis of the lumbar spine. The procedure included bilateral total facetectomy, bilateral intervertebral cage insertion and CBT pedicle screw fixation of the spine. The instrumented levels i ncluded L3 to S1, the L4 L5 being the most frequently fused level. For S1 screws, we used the penetrating endplate technique. The mean follow up of the patients was 6 months after surgery. Results. We noticed considerable postoperative improvement in both back and leg pain. The most frequently encountered complication was the pedicle fracture at the screw insertion site (6 cases). The mean blood loss, operation time and postoperative morbidity were significantly lower than in the conventional PLIF. We obse rved considerable improvement in VAS, SF 12 and ODI scores comparing to traditional techniques. Conclusions. The MIDLIF procedure is comparable to the more traditional PLIF in terms of successful fusion rates and clinical outcomes, but with the additional benefits of less muscle damage, less blood loss and earlier return to daily activities.