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SM ISO690:2012 ZVEAGHINTSEVA, Marina, STYNGACH, Evgenia, POGREBNOI, Serghei, BARBA, Alic, GERONIKAKI, Athina, DUKA, Gh., VALICA, Vladimir, MAKAEV, Fliur. Antifungal and antioxidant activity of (Z)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)-1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one. In: Topical issues of new drugs development: Abstracts оf XXIII International Scientific And Practical Conference Of Young Scientists And Student, 21 aprilie 2016, Kharkiv. Kharkiv, Ukraine: National University of Pharmacy, 2016, Ediția a XXIII-a, pp. 57-58. |
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Topical issues of new drugs development Ediția a XXIII-a, 2016 |
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Conferința "Topical issues of new drugs development" Kharkiv, Ucraina, 21 aprilie 2016 | |
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Pag. 57-58 | |
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Introduction. The treatment of fungal infectious diseases remains a challenging problem because of the increasing number of microbial pathogens. 1,2,4-Triazole derivatives templates is a privileged structure fragments in modern medicinal chemistry considering its broad pharmacological spectrum and affinity for various bio targets of these class heterocyclic compounds. The current interest in the development of new agents can be partially ascribed both to the increasing emergence of fungal resistance to antibiotic therapy and to newly emerging pathogens, reinforces the need for the development of new and potent chemical entities or an improvement in the activity of well-known 1,2,4-triazole derivatives. Considering this statement, the synthesis of analogues can be seen as an efficient approach to optimize an active chemical structure and design new drugs, since simple structural changes can lead to better biological activities through modifications of physicochemical properties.
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