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Articolul precedent |
Articolul urmator |
928 8 |
Ultima descărcare din IBN: 2023-05-14 12:40 |
SM ISO690:2012 VIŞNEVSCHI, Anatolie. Aspecte moleculare în patogenia şocului hemoragic
. In: Curierul Medical, 2010, nr. 1(313), pp. 61-66. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 1(313) / 2010 / ISSN 1875-0666 | ||||||
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Pag. 61-66 | ||||||
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Molecular Aspects of Hemorrhagic Shock Pathogenesis
Hemorrhagic shock (HS) results in the initiation of an inflammatory cascade that is critical for survival following successful resuscitation.
This is characterized by local and systemic release of pro-inflammatory cytokines, arachidonic acid metabolites, proteins of the contact phase and
coagulation systems, complementary factors and acute phase proteins, as well as hormonal mediators, together defined as systemic inflammatory
response syndrome. The immediate response genes iNOS and COX-2 promote the inflammatory response by the rapid and excessive production
of nitric oxide (NO) and prostaglandins. The hypoxic transcription inducible factor-1 (HIF-1) may regulate the induction of iNOS during the
ischemic phase of shock. NO-dependent NF-κB activation promotes the induction of inflammatory cytokine expression during the reperfusion
phase.
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Cuvinte-cheie hemorrhagic shock, inflammation, cytokines |
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