Polysulfone was used as an alternative base-polymer for designing new mixed ma-trix inclusion membranes that could oppose to astringent environmental conditions. The membranes were elaborated using polysulfone as polymer matrix, inorganic fillers, pol-yhedral oligomeric silsesquioxanes (POSS) and Aliquat 336 as a carrier in the absence of a plasticizer. Polysulfone was chosen as polymer matrix due to its superior chemical and thermal stability. These properties are associated with its special structure. The polysulfone is widely used as polymer matrix for the separation of CO2 as it is absorbed particularly into the polymer matrix. The relevant improvement in membrane preparation is represented by the addition of inorganic materials (POSS) and the ionic liquids (Aliquat 336) in polymer matrix to form the membranes. This addition has a relevant effect on the membranes gas separation performance as it is capable to modify the gas transport prop-erties through the membranes. Inorganic fillers such as POSS have been investigated in many fields of engineering and science and it was proved that they enhance the gas transport properties of the membranes. These additional materials can improve the per-meability of CO2 while maintaining a high selectivity towards CO2 gas. The presence of functional groups on the polysulfone, silsesquioxanes, Aliquat 336 and the synthesized polymer inclusion membranes were confirmed using Fourier Transformed Infrared Spec-troscopy. Scanning electron microscopy and atomic force microscopy indicated that the membrane surface was dense and the roughness increased with an increase in the filler concentration. The hydrophilicity of the membranes was studied and the results showed that an increase in filler concentration increases the membrane’s hydrophilicity. Thermal stability was analyzed and the membranes were found to be stable above 180⁰C. The objective of this research was to study the effect of the POSS’s and ionic liquid (Aliquat 336) introduction in the polysulfone matrix in order to use its in environmental applica-tions.