The content and quality of proteins are genetically determined characters. Individual complex of soybean proteins determines the economic values of the species. In order to identify the particularities of plant response to humic compounds, the polypeptide spectrum of soybean proteins extracted from seeds of two varieties with different drought resistant was analysed. The comparative analysis of protein spectra of extracted proteins from beans of the control plants highlighted the presence of common polypeptides to both studied sorts, and the presence of specific polypeptides for each genotype with a varying amount share appreciated through colorant intensity and band dimension. Protein spectra included polypeptide bands with molecular mass comprised between 106 and 20 kDa. Notable qualitative differences between polypeptide pattern of genotype with medium resistance to drought (Horboveanca) and those resistant (S4-04) were detected at the polypeptide level with Mr 104, 60, 43 kDa, present in resistant genotype and absent in medium resistant. Under our previous research was established that treatment of seeds with humic compound (LG) significantly increase productivity of soybean plants growing under field conditions, which determined substantial changes in the protein content and enhance grain biomass. From the reported data we conclude that the chemical compounds such as humic compounds may influence production potential of soybean and resulted substantial changes in the protein complex of the plant.