In the current economic context, characterized by fierce competition between economic agents on the market, in the conditions of globalization and the expansion of large trade networks, the development of a modern trade, adapted to the demands of consumers, requires the knowing and using of the best performing trade methods and technologies. An important role in providing the population with commercial services in the Republic of Moldova belongs to trade of the municipality of Chisinau, which has a share of over 75.5% in the internal trade in the country in the last years. Respectively, its level of development has a strong impact on satisfying the consumption needs of the population and on strengthening the economic sector of the republic. This article analyzes the current situation in the field of trade in Chisinau, identifies the priority strategic directions and the social orientation of the trade development in the municipality and imposes a systemic approach to the implementation process of public policies related to commercial activities until 2030. It offers the mechanisms and methods of implementing effective measures and procedures by using the tools of strategic and anti-crisis management for improvement the activities of this sector. The identification of strategic priorities and the substantiation of the Chisinau municipality's trade development strategy, aligned with European policies, has a major impact in the context of the European integration aspirations of the Republic of Moldova and the population's desire to increase the quality of life.