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![]() CHUMAKOV, Yurii, PETRENKO, Peter A., CODIŢĂ, Tatiana, TSAPKOV, Victor I., POIRIER, Donald, GULYA, Aurelian. Crystal structures of 5-Bromo-2-hydroxybenzaldehyde, 2-hydroxy-3- methoxybenzaldehyde, and 2-hydroxynaphthalene-1-carbaldehyde 4-(2-pyridyl) thiosemicarbazones. In: Crystallography Reports, 2014, vol. 59, pp. 207-212. ISSN 1063-7745. DOI: https://doi.org/10.1134/S1063774514020072 |
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Crystallography Reports | ||||||
Volumul 59 / 2014 / ISSN 1063-7745 /ISSNe 1562-689X | ||||||
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DOI:https://doi.org/10.1134/S1063774514020072 | ||||||
Pag. 207-212 | ||||||
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5-Bromo-2-hydroxybenzaldehyde, 2-hydroxy-3-methoxybenzaldehyde, and 2-hydroxynaphthalene-1-carbaldehyde 4-(2-pyridyl) thiosemicarbazones (I-III, respectively) were synthesized and their crystal structures were determined by X-ray diffraction. All these molecules are almost planar. The presence of bulky substituents at the terminal nitrogen atoms of these molecules does not lead to changes in the conformation of the thiosemicarbazide moiety. Depending on the nature of substituents in the phenol rings, the crystals are composed of either centrosymmetric dimers (I) or infinite chains (II and III). In the concentration range of 10-5-10-7 mol/L, thiosemicarbazones I-III selectively inhibit the growth of human myeloid leukemia HL60 cells. |
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Cuvinte-cheie Bulky substituents, Centrosymmetric dimers, Concentration ranges, Human myeloid leukemia, Methoxybenzaldehyde, Terminal-nitrogen, Thiosemicarbazides, thiosemicarbazone |
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