Aim: The comparative chemical study of the antioxidant activity in vitro in dry extracts obtained from vegetal products of Solidago virgaurea and S. canadensis species from the Republic of Moldova flora. Methodology: Two complementary in vitro chemical methods have been used in order to assess the antioxidant activity of Solidago species: ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) assay and the Ferrozine Test (assay of iron-binding antioxidant capacity). Results: The ABTS assay showed that leaf extracts from both Solidago species demonstrated the highest antioxidant activity (S. canadensis – 44.17 μM TEAC, S. virgaurea – 34.31 μM TEAC), followed by aerial part extracts (S. canadensis – 39.32 μM TEAC, S. virgaurea – 33.25 μM TEAC) and flower ones (S. canadensis – 35.37 μM TEAC, S. virgaurea – 30.92 μM TEAC). The comparative analysis of the antioxidant activity by the assay of iron-binding antioxidant capacity demonstrated an insignificant difference in the data results for the vegetal products of S. canadensis: the leaves were highlighted with a maximum chelation capacity (81.49%), followed by the aerial parts (80.19%) and flowers (79.65%). The same consecutiveness was maintained for the vegetal products of S. virgaurea: the maximum chelation capacity was recorded for leaves (80.19%), followed by aerial parts (79.55%) and flowers (79.01%). Conclusions: The current study demonstrated a high antioxidant activity for all the analyzed Solidago extracts. At the same time, we mention the fact that Solidago leaf extracts were distinguished by a significantly increased antioxidant activity in the case of both methods used. These results are starting points for further research that would investigate the antioxidant potential of Solidago species from the Republic of Moldova flora.