Bioorganic compounds are included in the composition of reproductive cells predominantly in the form of high molecular biocomplexes. Recent years studies show that this sialidase in association with the plasma membrane has important physiological significance for the cell. This enzyme is located on the plasma membrane not randomly, but in certain areas, called domains, which are membrane invaginations enriched in glycosphingolipids and kaviolin, and are resistant to non-ionic detergent X-100 treatment. Microdomains are extremely rich in various kinases and play an important role in cell physiology. And sialidase modulates the activity of the kinases, and hence cell response to certain signals, changing the qualitative and quantitative composition of glycolipids in these domains. The characteristic feature of glycolipids, what they differ from each other by N-neuraminic acid and fucose ratio and molar ratio of each of them to one of the carbohydrates in the main part of glycoprotein molecules. Our experiments showed that the content of sialic acid in bovine sperm ranges from 2,3±0,35 - 4,0±0,40 g/billion. It should be noted that, against expectations, the number of sialic acid in the cryopreservation of bovine sperm decreases. In addition to sialic acid studies, we studied the cryogenic changes of 6-deoxy-hexoses, which are widely represented in the various natural compounds, and therefore is of interest to elucidate their role in specificity and biological activity of cell. The experiments performed in the laboratory show that the number of 6-deoxy-hexoses in bulls’ spermatozoa after dilution is within the range of 10,1±0,34 mg/billion gametes.However, reproductive cells lose their number of 6-deoxy-hexoses already during cooling, when their content is changed by 19%. The further falling of test indicator occurs after freezing and thawing, when their number reaches only 80,5% compared with the refrigerated gametes. If neuraminic acid plays an anti-adhesive role masking special receptor side, the balance between sialo- and asialo-contained structures can determine cell adhesion and recognition. Therefore, specific sialic acid receptor is one of the mechanisms by which the cell modulates its potential of recognition and changes its behavior according to the influences of the environmental factors. Changes in the content of neuraminic acid and 6-deoxy-hexoses do not only alters the receptor side, it disrupts the charge of the molecules which influences the form of its oligosaccharide part, its non-covalent and electrostatic interactions with surrounding molecules, which may also modify the surface of the plasma membrane. The changing of the content of sialic acid and 6-deoxy-hexoses during cryopreservation of genetic resources may cause deformation of the membrane surface of gametes, change its architectonic, accelerate the aggregation of proteins on the surface, because the ability of glycoproteins and glycolipids to form local clusters can be controlled by the amount of inter-repulsive molecules of N-Acetylneuraminic acid which they carry. These changes at the level of 6-deoxy-hexoses and sialic acids sufficiently characterize the state of decay of the glycocalyx system and of the extracellular matrix. Reducing the total number of 6-deoxyhexoses and elevating levels of N-Acetylneuraminic acid indicates the membrano-destruction of its glycosaminoglycan component. This component is responsible for the membrane process of reception and stability, and high content of sialic acids shows the strengthening of the process of membrane separation components. Thus, glycoprotein and glycolipid complexes of bulls’ gametes which have as a part the carbohydrate component sialic acid, undergo some changes in the process of cryopreservation. It is interesting that the 6-deoxy-hexoses are subject to change as well. This leads to the need to take in consideration the identified changes during the development of cryoprotective media and identify the optimal conditions of cryopreservation.