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 SM ISO690:2012LEDEŢI, Ionuţ, ŞUTA, Lenuţa-Maria, MURARIU, Marius, CIRCIOBAN, Denisa, VLASE, Gabriela, LEDEŢI, Adriana, VLASE, Titus. Preformulation studies for selection of excipients for cholinesterase inhibitor tacrine. In: Central and Eastern European Conference on Thermal Analysis and Calorimetry, Ed. 4, 28-31 august 2017, Chişinău. Germany: Academica Greifswald, 2017, Editia 4, p. 476. ISBN 978-3-940237-47-7. |
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| Central and Eastern European Conference on Thermal Analysis and Calorimetry Editia 4, 2017 |
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Conferința "Central and Eastern European Conference" 4, Chişinău, Moldova, 28-31 august 2017 | ||||||
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Tacrine (IUPAC: 1,2,3,4-tetrahydroacridin-9-amine) is a chemical compound that acts as a reversible inhibitor and classical pharmacophore known as one of the main FDA approved drugs for AD [1]. Chemical structure of tacrine (1,2,3,4-tetrahydroacridin-9-amine) The selected excipients were starch, calcium lactate, lactose, mannitol, magnesium stearate, sodium carboxy-methyl-cellulose, PVP, sorbitol, talc and fumed silica. As investigation tools, FTIR spectroscopy was choose as first technique, in order to determine the compatibility of components under ambient conditions, and the results are correlated with the ones of PXRD patterns. Later, the influence of thermal stress over the stability of samples and the analysis of thermal-induced interactions was studied by using thermal analysis [2]. For the observed incompatibities, a possible mechanism of interaction between levodopa and excipients was discussed. |
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