Technologies of cement and concrete in the XXI century are developing according to exponential laws [1]. In the world, the volumes of their production increase and the importance of human life support. Composite cement, concrete, and additives to them are complicated by a complication of hydration reactions, processes of structure formation and formation of high properties. In principle, this situation is supported by an increase in the science intensity of materials science at the Interdisciplinary junction of the basic sciences. The boundaries of the methodology of research are widening considerably. Calorimetry and its methods are increasingly involved in the study of the production and use of cement and concrete. Three directions are distinguished, developed by the Kharkov calorimetric center of building materials science. Thermokinetic analysis (TKA) of hydration interaction based on differential isothermal microcalorimetry [2]: - The device for carrying out ТКА in isothermal and not isothermal conditions of hardening is developed; - The whole range of binders under normal, elevated (up to 180 ° C) and lower (around 0 ° C and lower) temperatures in the presence of organic and inorganic, individual and complex additives for various purposes has been studied; - According to quantitative signs of the rate and completeness of hydration, a thermokinetic classification of the regularities of hardening processes is proposed. Thermoporometry (TРМ) - a non-destructive method for studying the microstructure of cement paste on the basis of differential scanning calorimetry is justified from the viewpoint of the thermodynamics of surface phenomena in disperse systems [3]. - The influence of the conditions and peculiarities of the formation of the concrete structure in the range of 1.5-100 nm has been studied in detail in connection with the technological factors in the synthesis of cement stone and concrete. - The contribution of the capillary and gel components of the microporosity of the cement stone to the strength, density, permeability and durability of concrete is quantitatively determined. - The regularities of ice formation during freezing of hardening astringents are established. The methodology of temperature and time monitoring (TТМ) for controlling and regulating the hardening of concrete on the basis of semi-adiabatic calorimetry was developed and implemented in the practice of laboratory research and production work. A procedure for compatibility of additives with cement is proposed, taking into account the mechanisms of their action, technological specificity, and purpose. The integrated application of calorimetry, in our opinion, is the most effective and promising direction for scientific and technological purposes.