The main mission of the breeders is to obtain and develop new, distinct, uniform and stable plant varieties whose seeds maintain genetic purity and intrinsic quality, thusimproving features such as productivity, maturity, regional adaptation, disease resistance, and tolerance to diverse weather patterns. Soybean is the “king of beans” and is produced in both temperate and tropical areas of the world. Purpose of this research work consists in the creation of new hybrid soybean varieties which meet the modern production requirements. Plants breeding have been carried out in the Institute of Genetics, Physiology and Plant Protection of the ASM. Results. During the recent five years six soybean varieties have been involved into the State Testing. Four of them were included into the Register of Breeding Achievements of Moldova. The best of them which present a complex of economic useful traits were included into the breeding process for the development of high productive soybean hybrids. Soybeans varieties Stefanel and Laduta have been developed through a hybridization method. These varieties were created by the authors A. Budak, V. Celac, L. Coretchi and A. Cheban. The parental forms for variety Stefanel are as follows: the maternal one is the variety Irina and the paternal one − K-003. The seed productivity consist 17,5-35,3 q/ha. The beans protein content consist 38,9%, the oil content − 19,1%, the weight of 1000 beans − 113-152 g and vegetation period − 112-118 days. Plant height varies from55cm to 89 cm. It is characterized by a high setting level of the first seedpod (15-16 cm) and an enhanced drought resistance. As compared with the standard variety the variety Stefanel exceeds it in productivity by 3,75% in the testing by State Commission for Crops Variety in the 2015-2017period. The variety Stefanel manifested resistance to the following pathogens: Uromyces appendiculatus (Pers.) Link, Phomopsis sojae Lehman, Septoria glycines Hemmi and Fusarium Lk. ex Fr.The initial forms for variety Laduta consist as follows: the maternal one is the variety K-003 and the paternal one −Hodgson. The seedsproductivityconsist 18,1-33,9 q/ha, the protein content in beans − 38,9%, the oil content − 23,2%, the weight of 1000 beans −110-161 g and the vegetation period −110114 days. Plant height varies from 65 to 75 cm. It is characterized by a high setting level of the first seedpod (15-16 cm) and an enhanced drought resistance. As compared with the standard variety the variety Laduta exceeds it in productivity by 11% in the testing by State Commission for Crops Variety in the 2015-2017 periods. The variety Laduta manifested resistance to the following pathogens: U. appendiculatus, S. glycines, Fusarium spp. and Ph. sojae. The varieties Stefanel and Ladutahave been included into the Register of Breeding Achievements of Moldova from 2018. Conclusions. The new soybean varieties Stefanel and Laduta presented performance consistently in State trials in the past three years in Moldova. They presented good tolerance to the main soybean pathogens and drought in the local conditions.