Sesame (Sesamum indicum L.) is one of the highest of oil content among of oilbearing crops. Seeds contain about 63 % of the semi-drying oil, up to 19 % of protein, up to 17,5 % of soluble carbohydrates. Sesame is an introducent for Moldova. This thermophilic african plant has a long vegetative period and not always ripened in our region. Seeds wide use in confectionery, food, pharmaceutical industry exclusively in the form of import raw materials and also climate aridization of our region are the most relevant cause of carrying out of selection work on creation of sorts for our conditions. Creation of initial material for sort selection adapted for our climatic zone cultivation. To receive no more than 140-145 days length of vegetative period forms; with a dense arranged boxes, first order upright sprouts, poorly fall downed seeds, highly productive. A collection unknown origin sample of sesame from the Republican botanical garden (Tiraspol) used as initial material. The sample was characterized by very low productivity - 0,58–5,4 c/hectare, 100– 110 cm height of plants, 30-80 strongly cracked boxes and fall downed seeds when ripened. Mutant material was received by 60Со radiation of seeds in 2012. Sixth generation (M6) mutant forms were tested in 2017. They have a 129 - 134 days vegetative period length, a dense arranged boxes (up to 7,2 pieces on 10 cm of sprout length), 13 first order upright sprouts, 320-650 boxes/plant, high efficiency – 50,7-98,9 g of seeds/plant. Mutant forms surpass of initial sample indicators in a complex of signs. A physical mutagenesis use with the subsequent individual selection allowed to receive a number of complex valuable sign mutants of sesame which can be used in selection of sorts for our region.