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SM ISO690:2012 GONTA, Maria. The role of the natural antioxidants in the oxihaemoglobin oxidation and the diminution of nitrite oncentration
. In: Chemistry Journal of Moldova, 2007, nr. 1(2), pp. 67-77. ISSN 1857-1727. |
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Chemistry Journal of Moldova | ||||||
Numărul 1(2) / 2007 / ISSN 1857-1727 /ISSNe 2345-1688 | ||||||
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Pag. 67-77 | ||||||
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The paper includes the study of the inhibition of the process of methemoglobinization at oxidation with nitrites in the presence of sodium dihydroxyfumarate (DFH3 Na) and resveratrol (3,4’,5-trihydroxystilben). The experimental study was carried out by treatment of the erythrocyte mass by hemolysis and exposure to nitrite. The kinetic investigations were carried out in following conditions: [Resv] = (5.10-5 – 1.10-3) mol/l, [DFH3
Na] = 1.10-6 – 5.10-6 mol/l; [HbO2]=1.10-3mol/l; pH 7,1; t = 370
C. The rate of transformation of HbO2 in the presence of resveratrol and DFH3 Na was calculated from kinetic curves of consumption of the substrate and formation of MetHb obtained spectrophotometrically (λmax= 540 nm for HbO2 and λ max
=630 for MetHb). It has been found out that the introduction of resveratrol and DFH3 Na in the system HbO2 – NO2-causes the decrease of the auto oxidation factor ϕ DFH3Na approximately by 1.1 – 2.5 times and ϕ resveratrol by 1.1 – 1.7 times. The time of achievement of the maximum rate of oxidation of HbO2 dζ/dτ (where ζ is the rate of transformation of HbO2 in MetHb) increases while the phase of fast oxidation of HbO2 decreases with increase of content of inhibitors. The process of interaction of nitrites with reducers (such as DFH4, DFH3
Na, resveratrol and ( )-catechine) was carried out as well. It has been established that degree of diminishing of the concentration of nitrites in the system RedH2-NO2-decreases as follows: DFH4 |
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Cuvinte-cheie nitrite, haemoglobin, inhibitor of methemoglobinization |
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