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355.48+578.8:616-002.5-036.1 (1) |
Operațiuni de război în general. Tactică. Strategie. Teatru de război. Istoria campaniilor militare (162) |
Virologie (446) |
Patologie. Medicină clinică (7151) |
SM ISO690:2012 ELDHOLM, Vegard, PETTERSSON, John H.O, BRYNILDSRUD, Ola Bronstad, KITCHEN, Andrew, RASMUSSEN, Erik, LILLEBÆK, Troels, RONNING, Janne O, MENGSHOEL, Anne_Torunn Orunn, DEBECH, Nadia, ALFSNES, Kristian, BOHLIN, Jon, PEPPERELL, Caitlin, BALLOUX, Francois, KRUDU, V.. Armed conflict and population displacement as drivers of the evolution and dispersal of Mycobacterium tuberculosis. In: Proceedings of the National Academy of Sciences of the United States of America, 2016, vol. 113, pp. 1881-1886. ISSN 0027-8424. |
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Proceedings of the National Academy of Sciences of the United States of America | |
Volumul 113 / 2016 / ISSN 0027-8424 /ISSNe 1091-6490 | |
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CZU: 355.48+578.8:616-002.5-036.1 | |
Pag. 1881-1886 | |
Rezumat | |
The "Beijing" Mycobacterium tuberculosis (Mtb) lineage 2 (L2) is spreading globally and has been associated with accelerated disease progression and increased antibiotic resistance. Here we performed a phylodynamic reconstruction of one of the L2 sublineages, the central Asian clade (CAC), which has recently spread to western Europe. We find that recent historical events have contributed to the evolution and dispersal of the CAC. Our timing estimates indicate that the clade was likely introduced to Afghanistan during the 1979-1989 Soviet-Afghan war and spread further after population displacement in the wakeof the American invasion in 2001. We also find that drug resistance mutations accumulated on a massive scale in Mtb isolates from former Soviet republics after the fall of the Soviet Union, a pattern that was not observed in CAC isolates from Afghanistan. Our results underscore the detrimental effects of political instability and population displacement on tuberculosis control and demonstrate the power of phylodynamic methods in exploring bacterial evolution in space and time. |
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