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Ultima descărcare din IBN: 2020-03-24 20:38 |
SM ISO690:2012 TOFAN, Elena. Оптимизация лечения больных хронической сердечной недостаточностью с низкой фракцией выброса левого желудочка
. In: Curierul Medical, 2010, nr. 1(313), pp. 33-37. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 1(313) / 2010 / ISSN 1875-0666 | ||||||
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Pag. 33-37 | ||||||
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Optimal Treatment of Chronic Heart Failure with Low Ejection Fraction of the Left Ventricle
The author studied 60 patients between the ages of 48 and 72 years (average age – 62.2 ± 8.4) with chronic heart failure (CHF) of II-IV
functional class (FC) and the ejection fraction of the left ventricle (LV) less then 45%, which worsened the ischemic cardiopathia. Patients were
divided into three groups. The 1st group (n=20) took 50 mg of losartan once in 24 hours, the 2nd (n=20) – 10 mg of lisinopril in 24 hours and the
3rd group (n=20) – a combination consisting of losartan and lisinopril in a therapy program lasting 24 weeks. The combined therapy of losartan
and lisinopril produced a greater reduction of the clinical symptoms of CHF in comparison with the monotherapies. The influence of losartan,
angiotensin and their combination on the hemodynamics and morphofunctional parameters of the heart resulted in the diminishing of the left
atrium and ventricle and the enhanced contractility of the left ventricle.
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Cuvinte-cheie nsuficienţă cardiacă cronică, Losartan, remodelarea miocardului, Lisinopril |
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