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Articolul precedent |
Articolul urmator |
1163 41 |
Ultima descărcare din IBN: 2024-03-21 09:41 |
Căutarea după subiecte similare conform CZU |
618.2/3-06:616.151.5-091.8 (1) |
Științe medicale. Medicină (11143) |
Patologia sistemului circulator, a vaselor sanguine. Tulburări cardiovasculare (975) |
SM ISO690:2012 BOICIUC, Chiril, BADICEAN, Dumitru, SCURTU, Vitalie, PLÎNGĂU, Ecaterina, UŞURELU, Natalia, SACARĂ, Victoria. Trombofilia ereditară ca una din principalele cauze ale problemelor reproductive la femeile din Republica Moldova. In: Buletin de Perinatologie, 2015, nr. 1(65), pp. 61-68. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 1(65) / 2015 / ISSN 1810-5289 | ||||||
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CZU: 618.2/3-06:616.151.5-091.8 | ||||||
Pag. 61-68 | ||||||
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Miscarriage is considered one of the most common gestational complications and a major problem of contemporary society. Pregnancy losses have multiple causes, while thrombophilic complications have a higher percentage. In the last decade the research of hereditary thrombophilia associations with miscarriages has increased considerable and recently thrombophilia has been postulated as a cause of recurrent pregnancy loss (RPL). Research design was constructed as casecontrol type. The case group was represented by 274 patients with reproductive losses and control group by 68 patients with two or more births. The aim of this study was to identify genetic factors that lead to the formation of thrombosis (F2 G20210A, G1691A F5, VKORC1 C1173T and G1639A VKORC1), involved in fi brinolysis (PAI-1 4G / 5G), and their association with reproductive disorders. Odd ratio analysis revealed that mutation G1691A of F5 gene (Leiden mutation) (OR 6.86, 95%CI 0.90, 52.48, p<0.05) and G20210A mutation of F2 gene (OR 2.18, 95%CI 0.26, 18.13, p>0.05) were associated with two or more reproductive loss being a major risk factor for normal development of pregnancy. It was determined that the gene polymorphism of plasminogen activator inhibitor (PAI-1 4G/5G), which regulates fi brinolysis process does not infl uence the normal course of pregnancy. VKORC1 gene is responsible for the activation of vitamin K and therefore would indirectly infl uence blood homeostasis. Study of VKORC1 gene polymorphisms (C1173T, G1639A) revealed association of homozygous genotype (T1173T, OR 3.26, 95%CI 1.07, 9.91, p>0.05) with increased risk of complications during pregnancy. Obtain results emphasize the necessity of hereditary thrombophilia molecular screening in women with RPL. |
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Cuvinte-cheie RPL, Trombofi lie erditara, Leiden, Protrombin, gena VKORC1 |
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