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<creators>
<creator>
<creatorName>Tokarciuk, N.I.</creatorName>
<affiliation>Винницкий национальный медицинский университет им. Н.И. Пирогова, Винница, Ucraina</affiliation>
</creator>
<creator>
<creatorName>Cighir, I.V.</creatorName>
<affiliation>Винницкий национальный медицинский университет им. Н.И. Пирогова, Винница, Ucraina</affiliation>
</creator>
</creators>
<titles>
<title xml:lang='ru'>Роль α-1-антитрипсина при белково-энергетической недостаточности у детей первого года жизни</title>
</titles>
<publisher>Instrumentul Bibliometric National</publisher>
<publicationYear>2014</publicationYear>
<relatedIdentifier relatedIdentifierType='ISSN' relationType='IsPartOf'>1875-0666</relatedIdentifier>
<subjects>
<subject>toddlers</subject>
<subject>α-1-antitrypsin</subject>
<subject>protein-energy malnutrition.</subject>
</subjects>
<dates>
<date dateType='Issued'>2014-10-01</date>
</dates>
<resourceType resourceTypeGeneral='Text'>Journal article</resourceType>
<descriptions>
<description xml:lang='en' descriptionType='Abstract'>Background: Protein-energy malnutrition is rather common desease for toddlers nowadays. The statistics show that level of mortality among toddlers with protein-energy malnutrition is increasing. Сhanges of protein metabolism under protein-energy malnutrition have gradual and adaptive nature. Material and methods: We have examined 100 children with protein-energy malnutrition. Children’s age ranged from 1 to 12 months of life. Quantitative determination of α-1-antitrypsin was performed using immunoturbidimetric method. The folloving groups are specified: Group I (the main group n = 50) – toddlers with protein-energy malnutrition (PEM) with perinatal affection of the central nervous system (PA CNS). Group II (the comparison group n = 50) – toddlers with (PEM) without (PA CNS). The control group comprised practically healthy toddlers, whose physical
development corresponded to their age. Results: The results of the study of protein metabolism of toddlers with protein-energy malnutrition showed an increase of α-1-antitrypsin as compared with the control group and the comparison group (p < 0.05). In toddlers with PEM and PA CNS metabolism disorders are manifested by the
increase of 2-1-antitrypsin content in the blood serum unlike the index of control and comparison groups (р < 0.05). 2-1-antitrypsin, as the index of protein metabolism, had a high sensitization 82.5% and specificity 87.4% in toddlers with PEM, while the sensitization of common protein level made up 79.4% and its specificity only 41.3%.
Conclusions: Increased level of α-1-antitrypsin in the serum of blood of toddlers with protein-energy malnutrition indicates the predominance of catabolic processes. The determination of α-1-antitrypsin level in blood serum of toddlers with PEM, probably, may reflect not only protein metabolism disorder and protein-synthetic function of liver, but also the predominance of catabolic processes even at the early stages of this disease development.</description>
</descriptions>
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<format>application/pdf</format>
</formats>
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