The prison environment includes various types of vulnerabilities, starting with general ones, then referring to special and accentuated ones. The principle of the detainee's vulnerability is a sufficiently researched subject in the European scientific space, especially from the positions of bioethics and medicine. Respect for bioethical principles: human dignity and autonomy is a real controversy between theoretical expression and its realization in practice. De facto conditions and deprivation of human liberty alter both principles. A special contribution regarding their restoration is related to the influence and spiritual capacity of the convict.