Introduction. Antimicrobial resistance is a 50-year pandemic requiring interventions that are harmless to human health. In this context, bacteriophage therapy has been rediscovered, which, according to the literature, is considered the optimal solution to mitigate this phenomenon. The aim of this literature review is to construct a clear understanding of the possibilities, challenges, and needs that this innovation presents in terms of reducing antibiotic resistance. Material and methods. For this study, a search of the SCOPUS and PubMed databases was conducted using the keywords and BOOLEAN operators “AND,” “OR,” and “NOT.” The search yielded 911 scientific papers. After applying the inclusion/exclusion criteria, 40 papers were ultimately included in the final stage of the study. Results. Based on the literature reviewed, a SWOT analysis of the potential of bacteriophage therapy as a method to combat antimicrobial resistance was conducted. The research identified several advantages in favor of bacteriophages, such as high specificity and low toxicity, among others. Additionally, the study revealed several opportunities that modern medicine can exploit, including personalized therapy assisted by genetic engineering and the use of phages as adjuvants in antimicrobial and antifungal therapy. Conclusions. Antimicrobial resistance poses a significant global public health challenge, demanding prompt action. Bacteriophage therapy emerges as an alternative with multiple advantages and a promising long-term perspective.