Objective: Studying the particularities of musculoskeletal impairment in parasitic infections. Methods: We studied 38 patients who were diagnosed positively with different parasites (toxocara canis (16 subjects), toxocara cati (4), echinococcus granulosus (10), giardia intestinalis (4), ascaris lumbricoides (2) and 2 patients ascaris lumbricoides (associated with toxocara canis) in which musculoskeletal system disorders were present. The study included 17 men (44.74%) and 21 women (55.26%). The age of the patients varies from 18 to 63, the average being 39. Patients were investigated clinically and paraclinically for the exclusion of other causes of musculoskeletal impairment and for evaluation of pathological changes. Patients were reevaluated after antiparasitic treatment. Results: In the group of analyzed subjects 26 patients (68%) presented diffuse myalgia; 24 patients (63%) - localized muscle pain; 34 patients (89%) – joint pain of which 17.6% - monoarthritis, 58.8% - oligoarthritis, 23.5% - polyarthritis; 14 patients (37%) had swollen joints; 8 patients (21%) - reduction of joint mobility; 20 patients (53%) experienced bone pain and 95% (36 patients) had marked fatigue. Patients underwent specific treatments for the infesting parasitic agent. After treatment, the following characteristics are attested: Diffuse myalgia improved in 77%, localized muscle pain in 92%, arthralgia in 59%, swelling passed from all patients, mobility restored in 75%, bone pain improved in 80% and fatigue relieved in 83%. From the monitored laboratory tests we mention: until the antiparasitic treatment the total immunoglobulin E has values greater than 240 ng/ml in 29 (76%) of subjects, after the antiparasitic treatment values that exceed the norm are in 16 (42%) patients; C-reactive protein was greater than 5 mg/l in 32 (84%) patients and after treatment only in 6 (16%) persons; ESR was increased in 24 (63%) patients until treatment, and after treatment is greater than 10 mm/h in 4 (10.5%) cases; eosinophils with values greater than 5% are in all subjects and after treatment remain high in 23 (60.5%) patients. Conclusion: The impairment of the locomotor system is found in parasitosis having as substrate inflammatory, immune and allergic changes with various sites of musculoskeletal pathology. In cases of musculoskeletal impairment of nonelucidated etiology, parasite investigation should be considered for promptly decision of therapeutic management.