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SM ISO690:2012 CHEMORTAN, Maria I., BUBULICI, Cristina, TAMAZLICAR, Cristina. Severe HELLP syndrome: clinical case presentation. In: Міжнародний медико-фармацевтичний конгрес студентів і молодих учених: BIMCO, Ed. 1, 11-15 martie 2023, Chernivtsi. Chernivtsi: Bukovinian State Medical University, 2023, p. 7. ISSN 2616-5392. |
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Міжнародний медико-фармацевтичний конгрес студентів і молодих учених 2023 | ||||||
Conferința " Міжнародний медико-фармацевтичний конгрес студентів і молодих учених" 1, Chernivtsi, Ucraina, 11-15 martie 2023 | ||||||
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In comparison to preeclampsia, which affects 5.7% of pregnancies, HELLP syndrome affects 0.2-0.6% of all pregnancies. In 4–12% of preeclampsia patients, HELLP syndrome develops. In the absence of preeclampsia, the diagnosis of HELL syndrome is delayed, making it particularly dangerous due to the consequences. Severe HELLP syndrome complicated by DIC in postpartum Patient L, a 31-year-old woman with a pregnancy at 39 weeks’ gestation, was admitted to the hospital complaining of premature rupture of membranes (PROM) in the absence of uterine contractions. Her somatic anamnesis was complicated. Evaluation of her medical records revealed the physiologic course of the pregnancy. On admission, the arterial blood pressure (ABP) was 120/80 mmHg. The management was awaited to be expectative, according to guideline. However, 1 hour later, the patient complained of severe epigastric pain and an occipital headache. Laboratory exams are performed when ABP increases to the level of 180/110 mmHg. The magnesia therapy has started, but the symptoms of target organ damage persist, ABP – 150/100 mmHg. Therefore, lab exams revealed thrombocytopenia (120×109 g/l), increased values of transaminases (ALT-317 U/l, AST-500 U/l), and proteinuria (4.32 g/l). A diagnosis of severe preeclampsia complicated by HELLP syndrome was considered. Thus, the emergency caesarian section was performed. Patient L gave birth to a male intrauterine growth restricted new-born (2390 g) with an Apgar score of 7/7 points. Quantitative blood loss was estimated at 700 mL. Patient L was admitted to the intensive care unit following delivery. The postpartum period was complicated by the disseminated intravascular coagulation, laboratory confirmed by thrombocytopenia (45×109 g/l), hypofibrinogenemia (1,9 g/l), and increased D-dimer levels (3460 ng/mL), including: multiple petechiae on the body, hemorrhage elimination from the postoperative wound. Clinical management was carried out according to international recommendations, therefore, patient L was discharged from the hospital at the 11 day after delivery. HELLP syndrome is a severe complication of pregnancy, frequently seen in primiparous patients without prior pathology, and develop severe preeclampsia prior to delivery. It requires emergency management due to its unfavorable impact on the mother and the fetus. All the factors mentioned above cause the emergency finalization of the pregnancy, which is an important step in the management of the case. |
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