The aim of the work was to establish the diagnosis, effective measures for treatment and prophylaxis of staphylococcal infections at rabbits. As research objects served 25 cadavers of young rabbits and 96 breeding females. The diagnosis focused on the clinical examination of the herd, the morphopathological ap-pearance of the corpses, bacteriological studies of the biomaterial taken and the isolation of the pathogenic agent. As a result of bacteriological investigations, Staphylococcus au-reus was isolated from the pathological material. The treatment was established as a result of determining the sensitivity of the pat-hogen to antibiotics. For the prophylaxis of staphylococcal infections, it was recommended to observe the rules of hygiene, feeding (quality fodder and balanced ration), the plan of periodic disinfection and deratization. Also, performing daily clinical examinations of the herd, identifying sick animals with skin lesions, mamitis, rhinitis, auricular scabies; remo-val of spiky plants from feed and litter.