Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
253 7 |
Ultima descărcare din IBN: 2024-03-18 17:36 |
Căutarea după subiecte similare conform CZU |
54.057:547.858+615.014 (1) |
Obținere. Preparare. Izolare. Purificare etc. (51) |
Chimie organică (486) |
Farmacologie. Terapeutică. Toxicologie (1611) |
SM ISO690:2012 ERHAN, Tatiana, GARBUZ, Olga, UNGUR, Nicon, GULEA, Aurelian. Sinteza și cercetarea proprietăților farmacofore ale unor N-(dimetilfenil)hidrazincarbotioamide . In: Revista de Ştiinţă, Inovare, Cultură şi Artă „Akademos”, 2023, nr. 2(69), pp. 67-74. ISSN 1857-0461. DOI: https://doi.org/10.52673/18570461.23.2-69.07 |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Revista de Ştiinţă, Inovare, Cultură şi Artă „Akademos” | ||||||
Numărul 2(69) / 2023 / ISSN 1857-0461 /ISSNe 2587-3687 | ||||||
|
||||||
DOI:https://doi.org/10.52673/18570461.23.2-69.07 | ||||||
CZU: 54.057:547.858+615.014 | ||||||
Pag. 67-74 | ||||||
|
||||||
Descarcă PDF | ||||||
Rezumat | ||||||
The present study was focused on the synthesis of some N-(dimethylphenyl)hydrazine carbothioamides 1-4, that contain the following N-substituents: 2,4-dimethylphenyl; 2,5-dimethylphenyl; 2,6-dimethylphenyl; 3,4-dimethylphenyl, to increase lipophilicity and N-(dimethylphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamides 5-8, analogous of Triapine. The structural formula of the compounds was characterized by means of spectroscopy: FT-IR, 1H-, and 13CRMN, and the molecular structure, for the first time, by means of X-ray diffraction. The study of antioxidant activity has shown that all compounds 1-8 are powerful antioxidants. N-(dimethylphenyl)-2-(pyridin2-ylmethylidene)hydrazinecarbothioamides 5-8 were tested as inhibitors of MCF-7 (breast cancer) cell proliferation. It was found that all the compounds exhibit activity comparable to that of Doxorubicin, among them the compound N-(2,5-dimethylphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide 6, with IC50=0.8 μM/L, demonstrated the highest activity. |
||||||
Cuvinte-cheie synthesis, Hydrazinecarbothioamide, antioxidant activity, anticancer activity, sinteză, hidrazincarbotioamide, activitate antioxidantă, activitate anticancerigenă |
||||||
|