The relevance of the research topic is of heightened interest due to the accelerating changes taking place in the world. Changes in the external environment have a significant impact on the transformations taking place in the business models of organizations. Moldovan SMEs face a significant choice: to transform their activities, or not. Refusing to change could mean a loss of competitiveness and financial sustainability for these enterprises. The purpose of the study is to justify the need for transformational changes in business models under the influence of changes caused by the processes of Industrialization 4.0. The methods of this study include: the method of analysis of the conceptual framework, synthesis of the resulting evidence base and justification of the relevant conclusions. The paper also describes the results of empirical research conducted in the period January-April 2023, which was carried out using questionnaires, observation and interviewing. The main results of the study are: the justification of theoretical conclusions, the formation of elements of the business model undergoing transformation, conclusions about the specifics of change in the enterprises of the Republic of Moldova.