A novel example of double 6-exo-trig heterocyclization: Nitrile conversion to new anticancer active (HeLa cells) primary amine ionic liquids

Prodius Denis; Shah Hamid Saeed; Iqbal Jamshed; Macaeva Anastasia; Dimoglo Anatholy; Kostakis George E.; Zill Nicolas; Makaev Fliur; Powell Annie Katherine

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SM ISO690:2012

PRODIUS, Denis, SHAH, Hamid Saeed, IQBAL, Jamshed, MACAEVA, Anastasia, DIMOGLO, Anatholy, KOSTAKIS, George E., ZILL, Nicolas, MAKAEV, Fliur, POWELL, Annie Katherine. A novel example of double 6-exo-trig heterocyclization: Nitrile conversion to new anticancer active (HeLa cells) primary amine ionic liquids. In: Chemical Communications, 2014, vol. 50, pp. 4888-4890. ISSN 1359-7345. DOI: https://doi.org/10.1039/c3cc49759c

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Chemical Communications

Volumul 50 / 2014 / ISSN 1359-7345 /ISSNe 1364-548X

A novel example of double 6-exo-trig heterocyclization: Nitrile conversion to new anticancer active (HeLa cells) primary amine ionic liquids

DOI:https://doi.org/10.1039/c3cc49759c

Pag. 4888-4890

Prodius Denis¹², Shah Hamid Saeed³, Iqbal Jamshed³, Macaeva Anastasia², Dimoglo Anatholy⁴, Kostakis George E.¹, Zill Nicolas¹, Makaev Fliur², Powell Annie Katherine¹⁵

¹ Karlsruhe Institute of Technology, Institute of Nanotechnology,
² Institute of Chemistry of the Academy of Sciences of Moldova,
³ COMSATS Institute of Information Technology,
⁴ Gebze Institute of Technology,
⁵ Institute of Inorganic Chemistry, Karlsruhe Institute of Technology

Disponibil în IBN: 18 iulie 2023

Rezumat

Conversion of nitriles under mild conditions leads to a new class of primary amines, including room temperature ionic liquids, acting as efficient anticancer agents.

Cuvinte-cheie
MeSH Amines, animals, Antineoplastic Agents, Cell Line, cell survival, Cercopithecus aethiops, cyclization, HeLa Cells, Humans, ionic liquids, Molecular Conformation, nitriles, temperature, Vero Cells EMTREE drug terms amine, antineoplastic agent, ionic liquid, nitrile, amine, cyanide, ether derivative, ionic liquid, vincristine EMTREE medical terms animal, Cell Line, cell survival, Chemistry, Chlorocebus aethiops, conformation, cyclization, drug effects, HeLa cell line, human, temperature, Vero cell line, antineoplastic activity, article, controlled study, cyclization, cytotoxicity, drug metabolism, drug structure, human cell, IC 50, Room temperature