Many centuries „the security” represented the most important preoccupation of a one political entity, taking about an empire, a kingdom or a statenation. From foreign studies about the security to the Conception of the national security of the Republic of Moldova, this concept supported and supports a variety of definitions. But we will mention the fact that with reference at the notion of security there are concepts as: threatening, risk and danger. The diversity of the sources’ insecurity of a one state has various forms of occurrence, and between them it is hard to make a clear distinction. That is why the present study proposes for itself to identify parameters of impact of foreseeable effects (in economical, financial, political, social, cultural and military plan) on the national security of the Republic of Moldova. In the evaluation of risks and threats of the national security we have to realize that these one are not independent and can influence each other. Increase or decrease of importance of each one depends on complex of external elements and especially on the geopolitical situation of Republic of Moldova, where the interest of Big Powers in zone and European security system will be established. Is hard to imagine how will influence the risks under our security in conditions of non-integration and isolation. Republic of Moldova became from the “consumer” of stability in source of instability and regional insecurity because of lack of security strategy and geopolitical orientation in framework of regional security process and mechanisms. This is determined and by the fact that Republic of Moldova has no economic and natural resources potential for adequate economic development and its integration in economic globalization process.