The educational reform increased the autonomy of Higher Education Institutions (HEIs) in the Republic of Moldova. Normative regulation of resources by the state has turned into a performance-based and results-oriented management tool. HEIs seeks to improve the efficiency of their processes to direct more resources to improved quality and increased yield. Under these conditions, university managers need to know the state and dynamics of the managed system in order to make appropriate decisions to place the universities on top positions in the international rankings. Motivated by digitization processes, HEIs has recently been paying more attention to the development of high-performance Management Information Systems (MIS) to ensure an intelligent management of information, oriented towards strategic results. Through this paper, we want to present the state of affairs regarding the information systems in the HEIs of the Republic of Moldova and highlight what are the expectations for a MIS capable of improving the decision-making process in the HEIs to ensure national and international competitiveness.