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SM ISO690:2012 BOGONOVSCHI, Livia, REVENCO, Ninel. Cardiovascular manifestations in idiopathic juvenile arthritis. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 381. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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Pag. 381-381 | ||||||
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Background. Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease that triggers cardiovascular changes similar to other rheumatic conditions in adults over time. Inflammation as an isolated pathophysiological process is well studied and known, but less is known about the involvement of the inflammatory process in initiating endothelial dysfunction with the subsequent progression of atherosclerosis in juvenile idiopathic arthritis. Objective of the study. Research on cardiovascular risk factors in children with juvenile idiopathic arthritis. Material and Methods. The study included 90 children with JIA and 125 healthy children in the control group. Lipidogram was performed in all subjects, which included total cholesterol (TC) and triglycerides (TG), homocysteine (Hcy), as a non-traditional cardiovascular risk factor. Patients with JIA also had an ECG and echocardiographic examination. Results. Increases in TC were noted in 64.4% of children with JIA and in 14.4% of cases in the control group (p < 0.001). Elevated TG values in children with AJI were in 28.8% of cases and in 7.2% of cases in the control group (p > 0.05). In children with JIA the increase in serum Hcy level was noted at 67.7% of cases compared to 15.7% of cases in children in the control group (p < 0.001). Heart rhythm disorders were recorded in 44% of children with JIA, respectively tachycardia was noted in 20.7% of children, bradycardia - 11%, ventricular extrasystoles - 9.8% and supraventricular extrasystoles - 2.4%. Conclusion. Children with JIA have a higher risk of hypercholesterolemia and hyperhomocysteinemia compared to the control group. The inflammatory process present in these children supports the increase in TC and Hcy. |
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Cuvinte-cheie Juvenile idiopathic arthritis, total cholesterol, homocysteine, atherosclerosis, artrită juvenilă idiopatică, colesterol total, homocisteină, ateroscleroză |
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