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<creators>
<creator>
<creatorName>Rotaru, V.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Borş, E.T.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Hangan, C.A.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Cernit, V.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
</creators>
<titles>
<title xml:lang='ro'>Corelaţii dintre activitatea sistemului citokinic şi proteina C–reactivă pe parcursul şocului hemoragic</title>
</titles>
<publisher>Instrumentul Bibliometric National</publisher>
<publicationYear>2011</publicationYear>
<relatedIdentifier relatedIdentifierType='ISSN' relationType='IsPartOf'>1857-1719</relatedIdentifier>
<dates>
<date dateType='Issued'>2011-01-04</date>
</dates>
<resourceType resourceTypeGeneral='Text'>Journal article</resourceType>
<descriptions>
<description xml:lang='en' descriptionType='Abstract'>Causal correlation between systemic activity of cytokines and C- reactive
protein during hemorrhagic shock
Hemorrhagic shock takes place by local and systemic inflammatory processes. A
pathogenetic factor of systemic inflammation is acute-phase response. During the acute-phase
response, the liver dramatically increases the synthesis of acute-phase proteins, such as
fibrinogen and C-reactive protein (CRP). CRP is recognized as a true marker of local and
diffuse inflammatory process. Elevated levels of this protein of acute inflammation during
hemorrhagic shock are caused by elevated concentrations of cytokines IL-1, IL-6, TNF-α.</description>
<description xml:lang='ro' descriptionType='Abstract'>Şocul hemoragic se desfăşoară prin procese inflamatorii locale şi sistemice. Un factor
patogenetic al inflamaţiei sistemice este Răspunsul Fazei Acute (RFA). În timpul RFA în ficat
creşte corelativ sinteza proteinei C- reactive (PCR), fibrinogenului, precum şi nivelul citokinelor
în sânge. PCR este recunoscută drept un marker fidel al procesului inflamator local şi difuz.
Valorile crescute ale acestei proteine a fazei acute a inflamaţiei pe perioada şocului hemoragic
sunt determinate de concentraţiile elevate ale citokinelor IL-1-α, IL-6 şi TNF-α.</description>
</descriptions>
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