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 SM ISO690:2012POTLOG, Tamara, LUNGU, Ion, TIULEANU, Pavel, ROBU, Stephan V.. Photophysical properties of linked zinc phthalocyanine to acryloyl chloride:N-vinylpyrrolidone copolymer. In: Polymers, 2021, nr. 13(24), pp. 1-10. ISSN 2073-4360. DOI: https://doi.org/10.3390/polym13244428 |
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  Polymers |
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| Numărul 13(24) / 2021 / ISSN 2073-4360 | ||||||
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| DOI:https://doi.org/10.3390/polym13244428 | ||||||
| Pag. 1-10 | ||||||
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This paper focuses on the linking of zinc phthalocyanine (ZnPc) to N-vinylpyrrolidone (N-VP): acryloyl chloride (ClAC) copolymer. The synthesis of binary N-VP:ClAC copolymer was performed by the radical polymerization method and then grafted to ZnPc by the Friedel Crafts acylation reaction. We have developed a water-soluble ZnPc:ClAC:N-VP photosensitizer with a narrow absorption band at 970 nm, fluorescence at λem = 825 nm and the decay fluorescence profile with 3-decay relatively longer times of 1.2 µs, 4.6 µs, and 37 µs. The concentration-dependent dark cytotoxicity investigated in normal fibroblasts (NHDF), malignant melanoma (MeWo), adenocarcinoma (HeLa), and hepatocellular carcinoma (HepG2) cell lines incubated to increased concentrations of ZnPc:ClAC:N-VP (up to 40 µM) for 24 h in the dark show low cytotoxicity. Maximum cell viability in HeLa and HepG2 tumor cell lines was observed. |
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| Cuvinte-cheie absorbance, Acryloyl chloride, Dark cytotoxicity, Fluorescence emission, N-vinylpyrrolidone, The lifetime of the excited state, Zinc phthalocyanine, ZnPc:N-VP:ClAC solution |
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