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Ultima descărcare din IBN: 2023-03-14 18:22 |
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616.24-002.828-036.12:577.15 (1) |
Patologia sistemului respirator. Tulburări ale organelor de respiraţie (760) |
Bazele materiale ale vieții. Biochimie. Biologie moleculară. Biofizică (667) |
SM ISO690:2012 SELEVESTRU, Rodica, COTOROBAI, Mariana, BALANEŢCHI, Ludmila, TOMACINSCHI, Cristina, ROTARU-COJOCARI, Diana, ŞCIUCA, Svetlana. Infecția cu Aspergilus fumigatus la pacienții cu maladii cronice pulmonare. In: Buletin de Perinatologie, 2021, nr. 2(91), pp. 24-27. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 2(91) / 2021 / ISSN 1810-5289 | ||||||
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CZU: 616.24-002.828-036.12:577.15 | ||||||
Pag. 24-27 | ||||||
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Aim. Evaluation of Aspergilus fumigatus infection in lung damage in patients with chronic lung disease. Material and methods. The study included children with chronic bronchopulmonary diseases: 22 patients with CF (73,3%: 95%CI, 54,1-87,7 cases), with asthma 3 children (10%: 95%CI, 2,1-26,5), with unilateral lobe emphysema and pulmonary tuberculosis 2 children each (6,7%: 95%CI, 0,8-22,1) and obliterating bronchiolitis one child (3,3%: 95%CI, 0,1-17,2).The study was based on the analysis of the results of immunological investigations in serum. Quantitative assessment of anti-Aspergillus fumigatus antibodies (IgM, IgA, IgG) by indirect haemagglutination methods. The results are expressed as a titer (norm <1/80). Assessment of serum IgE concentration was performed by immunoenzymatic analysis. The materials were statistically analyzed with Microsoft Excel, Epi Info -3,5 programs. Results. The basic group consisted of 22 children with CF (9 boys 40,9%: 95%CI, 20,7-63,6 and 13 girls 59,1%: 95%CI, 36,4-79,3) and 8 children with chronic bronchopulmonary diseases (50%: 95%CI, 15,7-84,3 boys and girls). The total titer of Ac anti-Aspergillus fumigatus equal to 1:440±49,6 children in the baseline was assessed, and in children with chronic bronchopulmonary diseases the total titer of Ac anti-Aspergillus fumigatus was higher - 1:640±130,6, statistic T=1,8, p>0,05.Total serum IgE concentration in children with HR equal to 181,5±58,9 ME/ml, and children with chronic bronchopulmonary diseases 96,8±29,1 ME/ml, statistic T=0,74, p>0,05. Conclusion. Aspergilus fumigatus infection is confirmed by the increased titer of hiter-IgE-associated anti-Aspergillus fumigatus antibodies labeled in patients with cystic fibrosis. |
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Cuvinte-cheie Aspergillus fumigatus, cystic fibrosis, children, Aspergilus fumigatus, муковисцидоз, дети |
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