The study of etiological and pathogenetic mechanisms of development of immunodeficiency states (IDS) in different regions is one of the priorities of modern medicine. The frequency of their registration in different countries varies greatly (from 5.13 per 100 000 people in France to 1.9 – in Italy). The heterogeneity of their clinical manifestations and evolution,
the association with other nosological forms cause great difficulties in early diagnosis. In Moldova, there is no National Register of IDS. Pathological study of 2348 cases of death of children in one medical institution for a 10 year period showed 37 cases of primary immunodeficiencies, which represents 1.6% of total number of deaths. Scientific and practical conferences
in Health Centers showed low alertness of doctors on this issue. In this regard, the aim of the work was to develop the management of early detection of patients with suspected IDS. In this context, the increasing alertness of doctors of first
level medical care in relation to IDS is of great importance, especially in areas with high anthropogenic load. Among the criteria for selection of patients with suspected IDS it is necessary to highlight the frequency and spectrum of old diseases,
especially their evolution, the state of organs of the immune system, etc.
Aim of work: To study the nosological structure of pathologies "masking" immunodeficiency in children from Hincesti District. Methods: a retrospective analysis of medical records of 803 young patients in the period from January 2010 to January
2016 was made. Patients were screened for the presence of 2 or more signs of immunodeficiency of 10 signs proposed by WHO. Results: Leading pathology detected in children is the pathology of the bronchopulmonary system with varying degrees
of course – 63.9%, followed by intestinal infections, digestive disorders – 12.7%, and retard in development – 5.6%. Noteworthy is the fact that, children over 14–15 years have varying degrees of disability, and the majority of the examined (83%)
have a history of 3 or more severe pathologies.