Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
207 1 |
Ultima descărcare din IBN: 2022-04-03 16:18 |
Căutarea după subiecte similare conform CZU |
616.12-008.331.1]:616-007.2-053.2 (1) |
Patologia sistemului circulator, a vaselor sanguine. Tulburări cardiovasculare (978) |
SM ISO690:2012 PALII, Ina, EŞANU, Veronica, EŞANU, Valeriu. The role of proinflammatory cytokines in heart failure in children in combination with pulmonary hypertension. In: International Journal on Immunorehabilitation, 2016, nr. 1(18), pp. 49-49-1. ISSN 1562-3629. |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
International Journal on Immunorehabilitation | ||||||
Numărul 1(18) / 2016 / ISSN 1562-3629 | ||||||
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CZU: 616.12-008.331.1]:616-007.2-053.2 | ||||||
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Introduction: Proinflammatory cytokines play an important role in the pathogenesis of heart failure (HF), and in pulmonary |
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Cerif XML Export
<?xml version='1.0' encoding='utf-8'?> <CERIF xmlns='urn:xmlns:org:eurocris:cerif-1.5-1' xsi:schemaLocation='urn:xmlns:org:eurocris:cerif-1.5-1 http://www.eurocris.org/Uploads/Web%20pages/CERIF-1.5/CERIF_1.5_1.xsd' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' release='1.5' date='2012-10-07' sourceDatabase='Output Profile'> <cfResPubl> <cfResPublId>ibn-ResPubl-129622</cfResPublId> <cfResPublDate>2016-06-15</cfResPublDate> <cfVol>18</cfVol> <cfIssue>1</cfIssue> <cfStartPage>49</cfStartPage> <cfISSN>1562-3629</cfISSN> <cfURI>https://ibn.idsi.md/ro/vizualizare_articol/129622</cfURI> <cfTitle cfLangCode='EN' cfTrans='o'>The role of proinflammatory cytokines in heart failure in children in combination with pulmonary hypertension</cfTitle> <cfAbstr cfLangCode='EN' cfTrans='o'><p>Introduction: Proinflammatory cytokines play an important role in the pathogenesis of heart failure (HF), and in pulmonary<br />hypertension (PH). Aim: Determination of pathophysiological role of proinflammatory cytokines IL-1ß, IL-6 and TNFα in HF in children<br />secondary to congenital systemic-to-pulmonary shunts complicated with PH of different degree. Materials and methods: The study comprised 70 children: from 1 month to 18 years with HF secondary to systemic-<br />pulmonary shunts simple, compound and complex with PH (anatomical and pathophysiological classification, modified<br />from Venice 2003 ESC PAH Guide 2013). Depending on the degree of PH patients were divided into two: group I – 16 children with HF and moderate PH (PSAP 50–70% of the systemic) and group II – 54 children with HF and PH severe degree<br />(PSAP> 70% of the systemic). After FC NYHA / Ross, in the group I prevailed children with FC II and III, and in the<br />second – FC III and IV (p<0.001). The control group consisted of 10 kids basically healthy with innocent heart murmur. The groups were comparable by age and sex. Proinflammatory cytokines were determined by immunoferment screening method. Results: In the patients of group I the serum level of IL-1β was 3.71±0.37 pg/ml vs 10.49±1.56 in the II group (p<0.05) and 2.74±0.53 healthy children (p<0.05, p<0.001). The amount of IL-6 was 5.5±0.83 pg/ml in group I vs 8.61±0.83 in group<br />II (p = 0.05) and 1.63±0.62 in healthy (p <0.001). TNF-alpha level was 3.62±0.37 in group I compared with 6.88±0.9 in<br />group II (p>0.05) and in healthy controls – 1.82±0.91 pg/ml (p<0.05, p <0.001).<br />Conclusions: Proinflammatory cytokines IL1β, IL-6 and TNFα are relevant to the pathophysiology of HF secondary to<br />congenital shunts associated with PH, their levels increasing with the severity of this pathology – FC NYHA/ROSS of HF and level of PH.</p></cfAbstr> <cfResPubl_Class> <cfClassId>eda2d9e9-34c5-11e1-b86c-0800200c9a66</cfClassId> <cfClassSchemeId>759af938-34ae-11e1-b86c-0800200c9a66</cfClassSchemeId> <cfStartDate>2016-06-15T24:00:00</cfStartDate> </cfResPubl_Class> <cfResPubl_Class> <cfClassId>e601872f-4b7e-4d88-929f-7df027b226c9</cfClassId> <cfClassSchemeId>40e90e2f-446d-460a-98e5-5dce57550c48</cfClassSchemeId> <cfStartDate>2016-06-15T24:00:00</cfStartDate> </cfResPubl_Class> <cfPers_ResPubl> <cfPersId>ibn-person-18810</cfPersId> <cfClassId>49815870-1cfe-11e1-8bc2-0800200c9a66</cfClassId> <cfClassSchemeId>b7135ad0-1d00-11e1-8bc2-0800200c9a66</cfClassSchemeId> <cfStartDate>2016-06-15T24:00:00</cfStartDate> </cfPers_ResPubl> <cfPers_ResPubl> <cfPersId>ibn-person-43755</cfPersId> <cfClassId>49815870-1cfe-11e1-8bc2-0800200c9a66</cfClassId> <cfClassSchemeId>b7135ad0-1d00-11e1-8bc2-0800200c9a66</cfClassSchemeId> <cfStartDate>2016-06-15T24:00:00</cfStartDate> </cfPers_ResPubl> <cfPers_ResPubl> <cfPersId>ibn-person-57721</cfPersId> <cfClassId>49815870-1cfe-11e1-8bc2-0800200c9a66</cfClassId> <cfClassSchemeId>b7135ad0-1d00-11e1-8bc2-0800200c9a66</cfClassSchemeId> <cfStartDate>2016-06-15T24:00:00</cfStartDate> </cfPers_ResPubl> </cfResPubl> <cfPers> <cfPersId>ibn-Pers-18810</cfPersId> <cfPersName_Pers> <cfPersNameId>ibn-PersName-18810-3</cfPersNameId> <cfClassId>55f90543-d631-42eb-8d47-d8d9266cbb26</cfClassId> <cfClassSchemeId>7375609d-cfa6-45ce-a803-75de69abe21f</cfClassSchemeId> <cfStartDate>2016-06-15T24:00:00</cfStartDate> <cfFamilyNames>Palii</cfFamilyNames> <cfFirstNames>Ina</cfFirstNames> </cfPersName_Pers> </cfPers> <cfPers> <cfPersId>ibn-Pers-43755</cfPersId> <cfPersName_Pers> <cfPersNameId>ibn-PersName-43755-3</cfPersNameId> <cfClassId>55f90543-d631-42eb-8d47-d8d9266cbb26</cfClassId> <cfClassSchemeId>7375609d-cfa6-45ce-a803-75de69abe21f</cfClassSchemeId> <cfStartDate>2016-06-15T24:00:00</cfStartDate> <cfFamilyNames>Eşanu</cfFamilyNames> <cfFirstNames>Veronica</cfFirstNames> </cfPersName_Pers> </cfPers> <cfPers> <cfPersId>ibn-Pers-57721</cfPersId> <cfPersName_Pers> <cfPersNameId>ibn-PersName-57721-3</cfPersNameId> <cfClassId>55f90543-d631-42eb-8d47-d8d9266cbb26</cfClassId> <cfClassSchemeId>7375609d-cfa6-45ce-a803-75de69abe21f</cfClassSchemeId> <cfStartDate>2016-06-15T24:00:00</cfStartDate> <cfFamilyNames>Eşanu</cfFamilyNames> <cfFirstNames>Valeriu</cfFirstNames> </cfPersName_Pers> </cfPers> </CERIF>