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SM ISO690:2012 VEVERIȚA, Irina, ŞCHIOPU, Victor. Tumorile neuroendocrine ale tractului digestiv. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 378. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 378-378 | ||||||
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Background. The neuroendocrine tumors (NET) of digestive system are rare tumors, that develop from the APUD system cells, and manifest pleomorphic clinically, often generate dramatic clinical sindromes. Objective of the study. To study and describe clinical and morphological manifesations of NET of the digestive tract. Material and Methods. This study is a descriptive and retrospective one, where we analized the clinical cases of 27 patients that were diagnosticated and treated in IMSP IO during the period of 2017-2019 years. Results. Analyzing the study group, we determined that women are more affected that men (55,55% vs 44,45%) at the middle age of 62,27 years. The most affected organs are stomach (8 cases) and colon (7 cases), other organs are less affected: the pancreas (4 cases), rectum (4 cases), small bowel (3 cases) liver (1 case). In the majority of cases, the tumors were diagnosticated in III and IV stages, and were characterized by proliferative index Ki-67>2%. The clinical manifestations were in dependence by affected organ and type of tumor activity. Definitive diagnostic were based on histological investigation with imunohistochemistry examination (100%). Conclusion. Neuroendocrine tumors are rare, and there is posible to establish the diagnostic only with histological and imonohistochemistry investigation, that needs to be positive for the diagnostic of NET, which allows a classification corelated with the response to therapy and the prognosis of disease. |
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Cuvinte-cheie neuroendocrine tumors, Ki-67, immunohistochemistry, tumori neuroendocrine, Ki-67, imunohistochimie |
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